In 1986 Lightman et al (1986) first reported that the zinc level of ovarian tumor tissue was significantly lower than the level in benign tissue samples.
在1986年,Lightman等(1986)首次報導了卵巢腫瘤組織的鋅水平顯著低於良性組織樣本中的水平。
Consistent with a decrease in tumor zinc levels is the report of Bae et al. (2006), which showed that exposure of OVCAR-3 cells (ovarian cancer cell line) to zinc-supplemented medium results in decreased cell growth that involved increased apoptosis.
與Bae等報導的腫瘤鋅水平降低相一致。 (2006),其顯示OVCAR-3細胞(卵巢癌細胞系)暴露於補鋅培養基導致細胞生長減少,其涉及增加的細胞凋亡。
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727867/
Significantly higher levels of Mn-SOD protein expression were detected in the malignant tissues compared with normal tissues (p < 0.05).
與正常組織相比,在惡性組織中檢測到顯著更高水平的Mn(錳)-SOD蛋白表達(p <0.05)。
In experimental systems, suppression of Mn-SOD expression by small interfering RNA caused a 70% increase of superoxide in ovarian cancer cells, leading to stimulation of cell proliferation in vitro and more aggressive tumor growth in vivo.
在實驗系統中,通過小干擾RNA抑制Mn-SOD表達導致卵巢癌細胞中超氧化物增加70%,導致體外細胞增殖的刺激和體內更具侵襲性的腫瘤生長。
節錄自http://www.jbc.org/content/280/47/39485.full
因此Mn(錳)-SOD的提升應該是為了要對抗卵巢癌細胞
It induced apoptosis in ovarian cancer cells by, down-regulating Bcl-2 and up-regulating Bax expression.
通過下調Bcl-2和上調Bax表達誘導卵巢癌細胞凋亡。
節錄自https://www.ncbi.nlm.nih.gov/pubmed/26514477